The Clemson Tigers (7-1, 6-1 ACC) and Florida State Seminoles (2-6, 1-6) meet in Tallahassee, Fla. for a noon ET kickoff Saturday. Below, we analyze the Clemson-Florida State college football betting odds and lines, with picks and predictions.

1. Clemson vs Florida State Head-to-Head Record & Betting Trends - Clemson defeated Florida State, 45-14, at home in the most recent meeting between these two on October 12, 2019. Florida State is 20-13-0 in the 33 all-time head-to-head meetings with Clemson. Clemson has won the last five head-to-head matchups with Florida State.
2. College Football Line Movements for Las Vegas Casino and Sportsbook Odds for Clemson Tigers at Florida State Seminoles provided by VegasInsider.com, along with more NCAA Football information for your sports gaming and betting needs.

UPDATE (9:15 a.m. ET): The Clemson vs. Florida State game was postponed to a yet to be determined date.

The Tigers are No. 4 in the Amway Coaches Poll powered by USA TODAY Sports.

The over-under for Saturday's game is 63.5 points. The money line is Clemson at -10,000 and Florida State at +1,700. More FSU Seminoles coverage.

Clemson at Florida State: Betting odds, spread and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Thursday at 8:18 a.m. ET.

Money line: Clemson -10000 (bet $10,000 to win $100) Florida State +1700 (bet $100 to win $1,700)Against the spread/ATS: Clemson -35 (-115) Florida State +35 (-106)Over/Under: 63.5 (O: -106 U: -115)

Clemson at Florida State: Three things to know

Tigers QB Trevor Lawrence, the Heisman hopeful, is expected back after a two-game absence due to a positive COVID-19 test. He returned to practice this week and is expected to play for the first time since Oct. 24 against Syracuse.Clemson enters on an 0-3 ATS skid, and the Over has cashed in each of its past four outings. As favorites of 26 or more points, the Tigers are just 1-4 ATS this season, including 1-1 ATS in two road games in that situation.Florida State also enters on an 0-3 ATS slide, averaging just 18.3 points per game on offense while allowing 42.3 PPG during the three-game span. The Seminoles have allowed at least 28 points in each of their past six games against FBS opponents.

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Clemson at Florida State: Odds, betting lines, predictions and picks

Prediction

Clemson 52, Florida State 20

Money line (ML)

The Tigers (-10000) should win this game rather easily, but risking $10 to win a dime? No thanks. AVOID.

Against the spread (ATS)

FLORIDA STATE +35 (-106) was dumped 38-22 at NC State last weekend, and it was trampled 41-17 at home by Pittsburgh in its most recent home game on Nov. 7. Still, FSU has at least looked respectable on its home field this season, going 2-1 straight up and 1-2 ATS in the past three outings, including a straight up win over North Carolina on Oct. 17 as a 13.5-point underdog.

Lawrence might be a little rusty after a few weeks on the sidelines. Clemson will win, but FSU should be able to stay within five touchdowns on its home turf.

Clemson Vs Florida State Betting Line

Over/Under (O/U)

OVER 63.5 (-106) is worth a small-unit play. Clemson will do its fair share of scoring, it’s Florida State which is the concern. As long as the Seminoles can come close to their season scoring average of 22.0 PPG, this game will inch across the finish line in the fourth quarter as a successful Over play.

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Clemson Florida State Betting Line

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